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Symbol Name ID |
Sh3bp2
SH3-domain binding protein 2 MGI:1346349 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Submandibular lymph node enlargement |
| Disease(s) Associated with SH3BP2 | |
| cherubism |
| Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
abnormal osteoclast differentiation |
decreased B cell proliferation |
impaired macrophage phagocytosis |
stomach inflammation |
decreased transitional stage B cell number |
decreased pro-B cell number |
abnormal B cell number |
decreased B-1 B cell number |
increased marginal zone B cell number |
increased pre-B cell number |
increased osteoclast cell number |
increased monocyte cell number |
increased spleen red pulp amount |
abnormal spleen marginal zone morphology |
abnormal B cell physiology |
decreased IgA level |
decreased IgG1 level |
decreased IgG3 level |
decreased IgM level |
decreased immunoglobulin level |
abnormal marginal zone B cell physiology |
abnormal macrophage physiology |
abnormal osteoclast physiology |
abnormal circulating cytokine level |
increased circulating interleukin-12 level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal immune system organ morphology |
enlarged lymph nodes |
abnormal interleukin-6 secretion |
decreased tumor necrosis factor secretion |
increased tumor necrosis factor secretion |
increased inflammatory response |
spinal cord inflammation |
blepharitis |
joint inflammation |
liver inflammation |
myositis |
osteomyelitis |
lung inflammation |
dermatitis |
increased susceptibility to bacterial infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||
| Sh3bp2tm1.1Ics/Sh3bp2tm1.1Ics | |||||||||||||||||||||||||||||||||||||||||||||
| Sh3bp2tm1Bjro/Sh3bp2tm1Bjro | |||||||||||||||||||||||||||||||||||||||||||||
| Sh3bp2tm1Geha/Sh3bp2tm1Geha | * | ||||||||||||||||||||||||||||||||||||||||||||
| Sh3bp2tm1Rtpl/Sh3bp2tm1Rtpl | |||||||||||||||||||||||||||||||||||||||||||||
| Sh3bp2tm1.1Ics/Sh3bp2+ | |||||||||||||||||||||||||||||||||||||||||||||
| Sh3bp2tm1Bjro/Sh3bp2+ | * | ||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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